Chloride bicarbonate

Bicarbonate levels vary with acid-base balance.

In the kidney, Cl- reabsorption is increased when HCO3- reabsorption is decreased, and vice versa. Plasma [Cl-] thus tends to vary inversely with plasma [HCO3-], keeping the total anion concentration normal. A raised [Cl-] (producing a hyperchloraemic metabolic acidosis) may be seen with administration of large volumes of isotonic saline or isotonic saline-containing colloid solutions. Hyperchloraemia is also found with experimental salt water drowning but rarely seen in actual cases.

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