Botulism

An uncommon, lethal disease caused by the exotoxins of the anaerobe Clostridium botulinum. Botulism is most commonly a food-borne disease, especially associated with canned foods. It may be contracted by wound contamination with aquatic soils. The toxin is carried in the blood to cholinergic neuromuscular junctions where it binds irreversibly. Symptoms begin between 6 h and 8 days after contamination and are more severe with earlier onset. Botulism is diagnosed by isolating Clostridium botulinum from the stool or by mouse bioassay (survival of immunised mice and death of non-immunised mice when infected serum is injected).

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