Antimicrobial treatment

Drug

Dose

Organism

Acyclovir

10mg/kg 8-hrly IV

Herpes viruses

Amphotericin B

250mg-1g 6-hrly IV

Fungi

Ampicillin

500mg-1g 6-hrly IV

H. influenzae Gram negative spp.

Benzylpenicillin

1.2g 2-6-hrly IV

Strep. pneumoniae

Ceftazidime

2g 8-hrly IV

K. pneumoniae Ps. aeruginosa Gram negative spp.

Cefuroxime

750mg-1.5g 8-hrly IV

Strep. pneumoniae H. influenzae Gram negative spp.

Clarithromycin

500mg 12-hrly IV (250-500mg 12-hrly PO if less severe)

Atypical pneumonia Strep. pneumoniae

Erythromycin

1g 6-12-hrly (500mg 6-hrly PO if less severe)

Atypical pneumonia Strep. pneumoniae

Clindamycin

300-600mg 6-hrly IV

Anaerobes Gram negative spp.

Cotrimoxazole

120mg/kg/day IV

Pneumocystis carinii

Flucloxacillin

2g 6-hrly IV (500mg-1g 6-hrly PO if less severe)

Staph. aureus

Ganciclovir

5mg/kg 12-hrly IV (over 1h)

CMV

Gentamicin

1.5mg/kg stat IV(thereafter by levels—usually 80mg 8-hrly)

K. pneumoniae, Ps. aeruginosa Gram negative spp.

Metronidazole

500mg 8-hrly IV or 1g 12-hrly PR

Anaerobes

Teicoplanin

400mg 12-hrly for 3 doses then 400mg daily

Methicillin-resistant Staph.

aureus

Vancomycin

500mg 6-hrly (monitor levels)

Methicillin-resistant Staph.

aureus

Linezolid

600mg 12-hrly IV or PO

Methicillin-resistant Staph.

aureus

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