Activated Protein C has anti-inflammatory, anticoagulant and pro-fibrinolytic properties. Its beneficial effects in sepsis are most likely to be related to its anti-inflammatory properties. A large prospective randomised controlled trial demonstrated outcome benefit for patients with severe sepsis treated within 48h of presentation with a 96h infusion of 24pg/kg/h aPC. Most benefit was seen in those with >2 organ dysfunctions. The major side effect was bleeding so caution should be exercised in those at high risk of potentially catastrophic bleeding, e.g. concurrent coagulopathy, or a recent history of surgery, major trauma, head injury and/or peptic ulcer disease.
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Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.