Mendlewicz et al.(46) first reported possible genetic linkage between manic-depressive disorder and coagulation Factor IX (F9) at Xq27 in 11 pedigrees. Linkage with DNA markers on the X chromosome has been excluded, however, in other pedigrees.(33) More recently, Pekkarinen et al/47 evaluated 27 polymorphic markers on the X chromosome (Xq25-28 region) in one large Finnish family. Linkage was found between a marker located on Xq26 (AFM205wd2) and bipolar affective disorder. This marker is located about 7 cM centrimeric to the F9 locus. These results are extremely suggestive of X linkage and confirm the need for further investigation of this region with other markers.

Natural Depression Cures

Natural Depression Cures

Are You Depressed? Heard the horror stories about anti-depressants and how they can just make things worse? Are you sick of being over medicated, glazed over and too fat from taking too many happy pills? Do you hate the dry mouth, the mania and mood swings and sleep disturbances that can come with taking a prescribed mood elevator?

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