Mendlewicz et al.(46) first reported possible genetic linkage between manic-depressive disorder and coagulation Factor IX (F9) at Xq27 in 11 pedigrees. Linkage with DNA markers on the X chromosome has been excluded, however, in other pedigrees.(33) More recently, Pekkarinen et al/47 evaluated 27 polymorphic markers on the X chromosome (Xq25-28 region) in one large Finnish family. Linkage was found between a marker located on Xq26 (AFM205wd2) and bipolar affective disorder. This marker is located about 7 cM centrimeric to the F9 locus. These results are extremely suggestive of X linkage and confirm the need for further investigation of this region with other markers.

Defeat Depression

Defeat Depression

Learning About How To Defeat Depression Can Have Amazing Benefits For Your Life And Success! Discover ways to cope with depression and melancholic tendencies! Depression and anxiety particularly have become so prevalent that it’s exceedingly common for individuals to be taking medication for one or even both of these mood disorders.

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