Variation among stimulants

Methylphenidate and dextroamphetamine tend to have rather similar effects, (l57) although dextroamphetamine may cause more insomnia and emotional symptoms than methylphenidate/158) Individual children may respond better to one preparation than to another. (l59) If practitioners try both methylphenidate and dextroamphetamine at a wide range of doses for each child, the rate of positive behavioural response may be as high as 95 per cent. (l6°)

Long-acting preparations of stimulants are useful for non-compliant patients who think that taking medication at school is socially unacceptable and who find the cyclical nature of the stimulant's effects unpleasant. When given in equivalent doses, the immediate-release and sustained-release preparations of methylphenidate, dextroamphetamine, and pemoline(l24) are equally effective.

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