Tryptamine derivatives

Tryptamine (1H-indole-3-ethanamine) is a naturally occurring metabolite of tryptophan. It forms the parent nucleus of a wide range of hallucinogenic drugs, some entirely synthetic (LSD, N.N-dimethyltryptamine) but many naturally occurring in plants, fungi (psilocybin—the psychoactive component of 'magic mushrooms'), and occasionally animals. It seems unlikely that many tryptamines other than LSD and psilocybin will be used unduly in dance clubs because they possess few stimulant properties, and need to be smoked or injected because most are inactive by mouth unless taken with a monoamine oxidase inhibitor. An example of the latter is the combination of N.N-dimethyltryptamine (the hallucinogen) and harmine (the activator) in the hallucinogenic drink ayahuasca or caapi used in rituals by South American Indians. Drugs such a N.N-dimethyltryptamine may have adverse effects upon both the cardiovascular system and on temperature regulation. They may induce unpleasant hallucinogenic experiences.

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