Treatment response

Clinical experience suggests that intermittent explosive disorder may be less responsive to insight-oriented and more responsive to cognitive-behavioural therapies, particularly those stressing anger management.(1) Medications reported effective in intermittent explosive disorder or apparent intermittent explosive disorder, some in controlled trials, include antiepileptics (e.g. phenytoin, carbamazepine), thymoleptics (e.g. tricyclics, serotonin reuptake inhibitors, lithium, valproate), b-blockers, psychostimulants, and even antiandrogens.(1..,6,,12> Also, serotonin reuptake inhibitors, mood stabilizers, and antiepileptics may be effective for impulsive-aggressive behaviour in personality-disordered patients.(13)

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