The neurobiology of treatments

It seems quite likely that our understanding of the mechanism of action of drugs or treatments such as electroconvulsive shock, which are antidepressant, antimanic, or mood stabilizing (effective against both poles of bipolar illness), will continue to stimulate ideas about the neurobiology of the illnesses they treat. This approach results from a rather simple linking of the drugs' actions to the possible pathophysiology that they may be correcting. For the first time we are now seeing drugs that have been developed from plausible extrapolations of the neurobiology. The potential of CRH antagonists has already been noticed; neurokinin receptor antagonists that will prevent the action of substance P, another peptide transmitter with a stress profile, also appear to be putative antidepressant drugs. (57)

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