Despite the many uncertainties, there are now established facts about the neurobiology of schizophrenia (see Table ! and Table.2). There is ventricular enlargement and decreased brain volume. Although the cellular correlates remain poorly understood, they involve the size, density, and organization of neurones and their synaptic contacts (see Fig ! ). In vivo studies show differences in cerebral metabolism and other parameters of cerebral function, with a pattern indicative of aberrant connectivity between brain areas. Dopaminergic, 5-HT, and glutamatergic systems are all affected, but the specific details of their involvement in schizophrenia, and how they relate to the functional and structural findings, are still frustratingly unclear.

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