The efficacy of the SRIs, together with the lack of efficacy of adrenergic antidepressants in OCD, have suggested that serotonin is involved in the pathophysiology of OCD. This relationship was validated by research on serotonergic markers in OCD and by the challenge paradigm. (6) Which type of serotonergic receptor is involved in the pathogenesis and/or the mechanism of action of anti-obsessional drugs, is still unclear. Further studies are crucial for elucidating the role of serotonin in the pathophysiology and management of OCD.

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