As we have already seen, the age-related incidence of schizophrenia and schizophrenia-like disorders shows marked sex differences. Females are at much higher risk in the late-life population, and reported female-to-male ratios for groups of these patients have ranged from 4:1 to 20:1. This imbalance cannot be explained by the greater numbers of females in the age group and implies that there is something particular about the female sex which carries a higher risk of psychosis at this age.

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