Sertindole has been shown in several large-scale clinical trials to be antipsychotic with virtually no extrapyramidal side-effects. (12) However, it has been suspected of causing prolongation of the QTc interval, leading to serious cardiovascular complications, in sufficient numbers of patients to require close ECG monitoring at the initiation of treatment. It has, therefore, been withdrawn from use worldwide despite the fact that it appears to have the lowest potential for extrapyramidal side-effects of any agent other than clozapine.
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