Sanfilippo syndrome Prevalence and causes

This is an autosomal recessive disorder with four enzymatically different forms, namely types A, B, C and D, all of which are involved with the breakdown pathway of heparan sulphate. Type A is thought to be the most severe and the most common of the four types. All are associated with progressive mental retardation. Type A involves heparan sulphate sulphatase enzyme dysfunction and has been mapped to chromosome 17q25.3.(46) Type B involves N-acetyl-a-D-glucosaminidase and has been mapped on to chromosome 17q21.(47) Type C leads to deficiency of acetyl-CoA-a-glucosaminide- Wacetyltransferase; the locus for this may lie on chromosome 14 or 21.(48> Type D involves W-acetyl-a-D-glucosamine-6-sulphatase deficiency and has been mapped to chromosome 12q14. (49> The reported prevalence of Sanfilippo syndrome has varied from 1 in 25 000 to 1 in 324 617.

5 Secrets to Lasting Longer In The Bedroom

5 Secrets to Lasting Longer In The Bedroom

How to increase your staying power to extend your pleasure-and hers. There are many techniques, exercises and even devices, aids, and drugs to help you last longer in the bedroom. However, in most cases, the main reason most guys don't last long is due to what's going on in their minds, not their bodies.

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