Radiochemistry

To produce, for example, the radio-isotope [(11)C]raclopride (used to study striatal dopamine D2 receptors), protons are accelerated by a cyclotron to hit a target of nitrogen gas. The nuclear reaction produces [ (11)C]carbon dioxide ((11)CO2). (11)CO2 is converted to [(11)C]iodomethane which is then used to label a raclopride precursor to form [(11)C]raclopride. This radiosynthesis procedure requires rapid automated synthetic chemistry facilities. Following quality control procedures, to estimate specific activity and chemical purity, [(11)C]raclopride is injected intravenously into subjects lying in the PET camera ( Plate. 3). Importantly, the total mass of radiotracer injected is very small (typically less than 5 pg) and therefore the radiotracer has no pharmacological effect itself.

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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