Quetiapine has been shown to be as effective as typical antipsychotics, with fewer extrapyramidal side-effects and no effect on serum prolactin levels. (76 65) It does not appear to have efficacy comparable to clozapine for treatment-resistant patients. There is no evidence regarding efficacy of quetiapine in patients who fail to respond to risperidone or olanzapine. Preliminary data on the effect of quetiapine on cognition in schizophrenia suggests it may be superior to haloperidol in some domains of cognition.

It has a flat dose-response curve with some patients responding to 150 mg/day and others requiring 750 mg/day.(764) Average clinical dose appears to be between 300 and 500 mg/day. The median dose in the elderly is 100 mg/day.(64) There have not yet been data to suggest efficacy advantages over typical neuroleptic drugs but tolerability appears good because of its low side-effect profile. It is well tolerated by patients with Parkinson's disease.

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