Quantitative genetics

Anita Thapar and Peter McGuffin Patternsof inheritance

Mendel'sjaws Single-gene. disorders Continuoustraits

ComplexJisordersand .irregular. phenotypes

Po!ygen|c/mu!tifactoria!.thresho!d,mode!s

Single. .m1aJo,r..!o,c,us...m,ode,! .and...atyp,icaLpatt,erns,..o,f. .Mendelian.. in,h.eri.t.ance

Othermodels

Components.. of..phenptypic. variation

Non:additive...genetic.effects

Family,.twin,.and..adoption .studies

Family. . .studies

Methods

Ascertainment Age.corre.ction

Twin..stud,ies Asce^rtainment

Zygosity

Equ.a!.e,n.viron„m£nts... assumption Comparability... of.twins Adoption. .studies

Methpds..pf .analysis

Path..ana!ysis Mode! . fitting

Mu!tivariate...mode! .fitting Mump!e..regressipn .analysis

Segregation. .analysis Gene.mapping Linkage

Linkage.analysis

Mlethpds..basledn .on. .relative,. .pairs

Association

Chapter. References

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