Prevalence and age characteristics

Pick's disease as defined above is rare, with a prevalence of 1 to 2 per cent in post-mortem studies of dementia, (H) compared to a prevalence of 7.5 per cent of FLD and 40 to 50 per cent of Alzheimer's disease.^.8 Little is known about the true prevalence and incidence of FTD. It might be responsible for as much as 20 per cent of all early onset dementia.(l9> Most demographic data concern the grouping of FTD, not separating FLD and Pick's disease. The overall frequency of Pick's disease in a wider sense has been estimated at 24 to 60 per 100 000 in Minnesota and 30 to 60 in Switzerland. (?c> The estimated prevalence of FTD in the Netherlands is 10.7 per million between 50 and 60 years of age, and 28 between 60 and 70 years. (21 Pasquier et al.(22) diagnosed FTD in 4.8 per cent, and probable or possible Alzheimer's disease in 71.4 per cent of 1015 consecutive cases examined at the Memory Clinic in Lille, France. The marked geographic variation of the prevalence of FTD might be due to genetic and environmental factors, but it might also be influenced by differences in the diagnostic process. The prevalence of dementia with a mainly presenile clinical onset in motor neurone disease has been estimated at 2 to 6 per cent. (23)

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