There is a consensus from a number of studies as to which of those subjects with Parkinson's disease are most likely to suffer from dementia: older people, patients with Parkinson's disease of longer duration, subjects who have a greater severity of motor symptoms and signs of Parkinson's disease, and those who show greater physical disability. ^M6 Some studies have shown that Parkinson's disease in men or of late onset is more likely to be associated with dementia. (,9) In parkinsonism, as distinct from Parkinson's disease, the likelihood of dementia is closely related to the pathological changes that underlie the symptoms of parkinsonism, which include diseases in which dementia is a leading feature, such as Alzheimer's disease. The explanation of an apparent association between the treatment of Parkinson's disease with levodopa and dementia is probably that successful treatment of the motor symptoms of Parkinson's disease prolongs life and thereby increases the risk of dementia.
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