Neuropsychological data provide a further line of support for the involvement of certain brain areas and their connections in the neurobiology of schizophrenia.

Intellectual impairment is a feature of schizophrenia. (15) It is present in first-episode, untreated patients, and worsens in the first few years of illness, warranting the label dementia in severe, chronic cases (see below). (16) Against a background of global decrement(!7) there is evidence for greater deficits in semantic memory, executive functioning, and attentional domains. (18) Anatomically, this neuropsychological pattern is in keeping with the preferential involvement of temporal lobe and frontostriatal circuits in schizophrenia identified by functional imaging.

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