Neurophysiology

There are two aspects of sensorimotor functioning in schizophrenia relevant to the study of its neurobiology. First, evoked potentials (electrical activity in the brain measured after a brief sensory stimulus) are altered. In particular, the P300 component is reduced and delayed in response to auditory and visual stimuli, indicative of impaired sensory processing and further implicating the temporal lobes in the pathophysiology of the disorder. (!3) Second, there is a high rate of eye movement abnormalities in schizophrenia,(!4) especially affecting smooth pursuit tracking, suggestive of impairment in the neural pathways subserving oculomotor control.

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