Nature of neuropsychiatric disorders in HIVinfected patients

Neuropsychiatric disorders are common in HIV-infected patients, and they can be either primary or secondary. Primary complications are those that can be attributed directly to the infection of the central nervous system by the virus, or to immunopathological events precipitated by HIV infection. Primary HIV-related brain disorders include HIV-related dementia and minor cognitive disorder.(2) Immune suppression can lead to a variety of secondary complications affecting the brain, including opportunistic infections (e.g. cerebral toxoplasmosis and progressive multifocal leucoencephalopathy) and tumours (e.g. cerebral lymphoma). Secondary complications in the form of acute and subacute syndromes (e.g. delirium) often occur as a result of cerebrovascular complications and toxic states induced by various therapeutic agents.

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