Mode of action

Some patients who drink while taking naltrexone report that they feel less of the ethanol 'high'. This could lead to less impulse to carry on drinking. (586°) However, O'sMalley et al.'(5,6) found that more patients reported total abstinence as well as a reduction of drinking overall. It is possible that the reduced craving for alcohol and the reduced likelihood of picking up the first drink occur because the strength of the previous triggers—emotional, cognitive, or environmental—is attenuated.

Reports in the 1970s that naltrexone might cause dysphoria seemed to be supported by statements from heroin addicts given naltrexone to help them abstain from opiates. However, laboratory studies and randomized controlled trials have not found evidence of dysphoria or loss of feelings of pleasure. (6D

Funny Wiring Autism

Funny Wiring Autism

Autism is a developmental disorder that manifests itself in early childhood and affects the functioning of the brain, primarily in the areas of social interaction and communication. Children with autism look like other children but do not play or behave like other children. They must struggle daily to cope and connect with the world around them.

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