Mechanism of action

MDMA ingestion leads to an acute increase in central serotonergic effects by causing the calcium-dependent release of serotonin from nerve terminals. To a lesser extent there is also dopamine reuptake blockade. MDMA also results in a rapid inhibition of tryptophan hyrdroxylase, the rate-limiting enzyme in serotonin synthesis, although the mechanism of inactivation in uncertain. This is followed by acute depletion of central serotonin levels which may contribute to the fall in mood that some users notice after use.

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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