Ltype calciumchannel blockers

Because so few patients have been studied with the L-type calcium-channel blockers in long-term prophylaxis, it is uncertain to what extent patients may become tolerant to these agents. However, since tolerance has been observed to virtually every other putative mood-stabilizing agent, it is likely that this will also occur with nimodipine and related agents. Similarly, it is uncertain whether the phenomenon of discontinuation-related refractoriness observed with lithium would extend to the class of L-type calcium-channel blockers; while we have not observed this phenomenon in our cohort of nimodipine responders, (63) only a small group of patients has been studied to date.

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