Ltype calciumchannel blockers

The pharmacokinetics of the L-type calcium-channel blockers are outlined in Table.2. Notably, amlodipine has a longer half-life and is suitable for single night-time or twice-daily dosing in comparison with the better psychiatrically studied drugs nimodipine and isradipine. However, as long-acting preparations of these compounds become available, the importance of this half-life dissociation among the different compounds may dissipate. In our patient cohort at the National Institute of Mental Health, the pharmacokinetics of nimodipine (Bay e 9736) and its several metabolites (Bay o 1762, Bay m 5397, and Bay m 8922) were characterized by a rapid peaking (in 30-45 min) and decline in the second hour in response to a 60-mg challenge dose at steady state blood levels after an overnight fast. Additional small secondary peaks occurred when usual dosing of four times a day was resumed. There were no notable differences between capsule and tablet preparations.

Table 2 Half lives, dosages, and effectiveness of L-type calcium-channel inhibitors in mood disorders

Beat Depression Today

Beat Depression Today

I know this is hard for you to believe. I mean, to be able to be totally free of depression in such little time... and without any effort... not to mention the freedom to live your life, appear hard to fulfill at first glance... That is until you know the facts On a subconscious level, you will experience an incredible and exclusive Tri- Enhanced trance state of hypnosis to reprogram your mind to free you from negatize emotions.

Get My Free Ebook


Post a comment