Local circuits

Hippocampal neurones are not just arranged as a simple synaptic relay where afferents excite target cells to produce an output depending on the size of the input and the state of inhibition at that time. Instead there exists a complex synaptic network, or local circuit, interlinking neurones of all kinds ( Fig 1 gives a very much simplified illustration of some of the salient features of hippocampal local circuits). This chapter considers two kinds of emergent network activity that arise from this organization: focal epilepsy and gamma rhythms.

Experimental approaches

Unravelling the cellular and network mechanisms of emergent network phenomena depends on a combination of electrophysiology, pharmacology, anatomy, and realistic computer simulations. Two practical issues may need a brief introduction

Funny Wiring Autism

Funny Wiring Autism

Autism is a developmental disorder that manifests itself in early childhood and affects the functioning of the brain, primarily in the areas of social interaction and communication. Children with autism look like other children but do not play or behave like other children. They must struggle daily to cope and connect with the world around them.

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