Local circuits

Hippocampal neurones are not just arranged as a simple synaptic relay where afferents excite target cells to produce an output depending on the size of the input and the state of inhibition at that time. Instead there exists a complex synaptic network, or local circuit, interlinking neurones of all kinds ( Fig 1 gives a very much simplified illustration of some of the salient features of hippocampal local circuits). This chapter considers two kinds of emergent network activity that arise from this organization: focal epilepsy and gamma rhythms.

Experimental approaches

Unravelling the cellular and network mechanisms of emergent network phenomena depends on a combination of electrophysiology, pharmacology, anatomy, and realistic computer simulations. Two practical issues may need a brief introduction

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