Irondeficiency anaemia

When erythrocyte-cytoplasm production is abnormally low due to the reduced production or availability of one of the three components of haemoglobin (iron, globin, or haem), the ratio of cytoplasm to the contents of the rest of the cell declines. This results in a microcytic anaemia. The mean corpuscular volume will fall below normal. In most cases, microcytic anaemia is due to iron-deficient haemopoiesis. Iron deficiency is usually due to an iron-poor diet or defective iron utilization by the body. In the early stages of iron-deficiency anaemia, few symptoms are encountered. (89 As the severity progresses, symptoms become obvious. Patients have severe fatigue, pallor, changes in nail curvature ('spoon nails'), and, at times, pica and cheilosis at the corners of the mouth. A diminished haematocrit and mean corpuscular volume, and low serum iron confirm the diagnosis. The 'gold standard' for diagnosing iron deficiency is the absence of iron on bone-marrow biopsy. The profound fatigue associated with iron deficiency can be misdiagnosed as major depressive disorder; treatment with an antidepressant will not help. Iron replenishment to correct the underlying deficiency is the recommended treatment. If possible, iron is given orally. When oral medication fails, or when the oral preparation cannot be tolerated due to gastrointestinal adverse effects, parenteral administration is necessary. With iron replenishment, the haemoglobin should correct to normal, and symptoms resolve, within 4 to 6 weeks.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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