Prominent atrophy of the medial temporal lobes on CT or magnetic resonance imaging is indicative of AD rather than DLB. (i8> Single-photon emission CT (SPECT) HMPAO imaging shows generalized reductions in cortical uptake, similar to AD. [ 123I]IBZM and [123I]FP-CIT are novel SPECT ligands that label postsynaptic D 2 receptors and the presynaptic dopamine transporter site, respectively. Both show marked changes in the caudate-to-putamen ratio in DLB, reflecting nigrostriatal dysfunction, and may prove to be sensitive and specific in the discrimination from AD and other non-Lewy body disorders. (19> Early slowing of dominant electroencephalography rhythms is characteristic of DLB, being associated in 50 per cent of cases with focal delta-wave transient activity in temporal regions. (20>

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