Introduction

Until the early part of the twentieth century, physicians were capable of little more than prescribing placebos. It has been estimated that of the 2000 'drugs' used in ancient China, virtually all lacked specific disease-relevant effects. (1) Cinchona bark (quinine) and foxglove (digitalis) were used in the eighteenth century, but their appropriate widespread use did not occur for centuries.(2) Although a part of medicine since its infancy, only recently have placebos played a salient role in drug development.

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