Introduction

The discovery by Delay and Denicker in 1953 that chlorpromazine was effective in treating core psychotic symptoms, i.e. delusions, hallucinations, and disorganized thinking, was one of the most important ever made in psychiatry and among the most important in all of medicine. Chlorpromazine and the other antipsychotic drugs which followed have proven to be of immense benefit to vast numbers of people who experience psychotic symptoms as a component of a diverse group of neuropsychiatric and medical disorders, as well as the result of adverse drug reactions. These drugs have been invaluable in providing clues to the aetiology of schizophrenia and other forms of mental illness with psychotic features and as tools in understanding fundamental neural processes, especially those involving dopamine, the key neurotransmitter involved in psychosis. This chapter will describe the various classes of antipsychotic agents, with emphasis on the newer classes of agents, their mechanism of action, their benefits and adverse effects, and recommendations for their use in clinical practice. The drugs used to treat the extrapyramidal side-effects produced by these agents are also considered.

Funny Wiring Autism

Funny Wiring Autism

Autism is a developmental disorder that manifests itself in early childhood and affects the functioning of the brain, primarily in the areas of social interaction and communication. Children with autism look like other children but do not play or behave like other children. They must struggle daily to cope and connect with the world around them.

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