Introduction

Huntington' disease was first described in 1872 by an American physician who lived on Long Island, New York. His father and grandfather practised medicine in the same community, and thus he had access to case notes from several generations of families living in the area. This long period of record keeping allowed him to document a hereditary form of chorea, similar to 'common (Sydenham') chorea', but progressing over many years to death. Its sufferers had a tendency to insanity and suicide. Huntington' brief essay, which also included a clear description of the autosomal dominant inheritance of this disorder, remains one of the classical descriptions of a medical disorder.(1)

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