Lamotrigine does not appear to affect the kinetics of other antiepileptic drugs or oral contraceptives, but its own kinetics are markedly affected by the concomitant administration of other antiepileptic drugs. Valproate inhibits the metabolism of lamotrigine, resulting in a doubling of the half-life to almost 60 h. The enzyme-inducing antiepileptic drugs, such as carbamazepine and phenytoin, decrease the half-life to approximately 15 h. These interactions necessitate dosage adjustments when starting lamotrigine (see discussion of dosageianid.admjnisirit,!9D below).(33>

5 Secrets to Lasting Longer In The Bedroom

5 Secrets to Lasting Longer In The Bedroom

How to increase your staying power to extend your pleasure-and hers. There are many techniques, exercises and even devices, aids, and drugs to help you last longer in the bedroom. However, in most cases, the main reason most guys don't last long is due to what's going on in their minds, not their bodies.

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