Hypopituitarism

Hypopituitarism is when multiple pituitary hormone secretion is diminished. It can be due to either gland destruction or inadequate stimulation by factors that regulate pituitary functioning. Common causes of hypopituitarism are pituitary adenomas, hypothalamic tumours, metastatic carcinoma (especially breast and bronchus), and cerebral trauma and haemorrhage/73) Other causes include vascular disorders, immunological conditions, and a variety of congenital anomalies. Clinical manifestations depend on which hormones are deficient; signs and symptoms are those of the individual deficiency states described previously. Other signs that may be present when there is hypopituitarism include headache, visual loss, and radiographically discovered sella enlargement. Treatment of patients with hypopituitarism involves hormone replacement therapy and surgery when accessible lesions are present. (73>

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