Prolactin is synthesized in the pituitary gland. Prolactin secretion is increased during pregnancy, enhancing breast development. Secretion is stimulated by oestrogen. Though prolactin secretion is inhibited by glucocorticoids and thyroid hormone, it is predominantly under the inhibitory control of dopamine. (73> That is why dopamine blocking medications such as neuroleptics can cause hyperprolactinaemia. Symptoms of hyperprolactinaemia include breast development and lactation. These bothersome side-effects of neuroleptics, particularly in men, can be modulated by changing to a more favourable neuroleptic medication.

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