Global assessment

Driven largely by the United States Food and Drugs Administration, global assessment has become part of the assessment of all patients with AD in clinical trials and is finding its way into clinical practice. The underlying premise is that an assessment by a clinician, often supplemented by an informant history, provides information on severity that neither a cognitive assessment nor a functional assessment alone can provide. One scale, the Clinicians Interview of Change, has become widely used in this context and is an interesting attempt to semiformalize the routine clinical impression without operationalized criteria.

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