Evidence for 5HT disruption in humans

Markers for 5-HT damage may be sought either by direct assessment of metabolite levels or indirectly by assessing those functions thought to be dependent on an intact 5-HT system. Subjects with prior exposure to MDMA had lower cerebrospinal fluid 5-hydroxyindole acetic acid than matched controls and lower levels of impulsivity, indirect hostility, and harm avoidance (I§b!e2). The 5-HT system is implicated in cognition, sex, sleep, and appetite, as well as mood. Uncontrolled human studies have reported cognitive deficits such as impaired immediate and delayed recall in those with a history of MDMA use, and recent work suggests acute mood and cognitive deficit in the days following use.


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