Evidence for 5HT disruption in humans

Markers for 5-HT damage may be sought either by direct assessment of metabolite levels or indirectly by assessing those functions thought to be dependent on an intact 5-HT system. Subjects with prior exposure to MDMA had lower cerebrospinal fluid 5-hydroxyindole acetic acid than matched controls and lower levels of impulsivity, indirect hostility, and harm avoidance (I§b!e2). The 5-HT system is implicated in cognition, sex, sleep, and appetite, as well as mood. Uncontrolled human studies have reported cognitive deficits such as impaired immediate and delayed recall in those with a history of MDMA use, and recent work suggests acute mood and cognitive deficit in the days following use.

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5 Secrets to Lasting Longer In The Bedroom

5 Secrets to Lasting Longer In The Bedroom

How to increase your staying power to extend your pleasure-and hers. There are many techniques, exercises and even devices, aids, and drugs to help you last longer in the bedroom. However, in most cases, the main reason most guys don't last long is due to what's going on in their minds, not their bodies.

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