Epidemiology and demographics

Prevalence estimates range from 1 per 12 000 to 1 per 23 000 females; cases are observed in all racial and ethnic groups. (6,62) Rett's syndrome may account for one-quarter to one-third of progressive developmental disabilities among females. (61)

To date, Rett's syndrome has been unequivocally described only in females. While male sex is not exclusionary diagnostic and case reports of males with some features of Rett's syndrome have been appeared, no male who exhibits strict diagnostic criteria has yet been identified. (56)

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