Effects of withdrawal

As with other antiepileptic drugs, lamotrigine should be tapered gradually over several weeks to avoid rebound seizures. Dosage and administration

Lamotrigine must be started at a low dose and increased with caution to a therapeutic dosage to minimize the risk of rash. The patient should be informed of the risk of developing a rash, and instructed to contact the physician immediately if one appears. The starting dose depends upon the concomitant administration of other antiepileptic drugs. Table 1 shows the dosage forms.

• Adults already taking valproate: lamotrigine should be started at 25 mg every other day for the first 2 weeks, followed by 25 mg every day for the next 2 weeks. After the first 4 weeks, the daily dosage can be increased by 25 to 50 mg/day every 1 to 2 weeks. The recommended maintenance dose is 100 to 200 mg/day in two divided doses.

• Adults already taking carbamazepine or phenytoin: lamotrigine should be started at 50 mg every day for the first 2 weeks, followed by 50 mg twice a day for the next 2 weeks. Thereafter, the dose can be increased by 100 mg/day every 1 to 2 weeks in order to achieve the usual maintenance dosage of 300 to 500 mg/day.

• Adults starting monotherapy: lamotrigine should be started at 25 mg every day for the first 2 weeks, followed by 50 mg every day for the next 2 weeks. Thereafter, the dose may be increased to a maintenance dosage of 100 to 200 mg/day, in two divided doses.

Therapeutic plasma concentrations of lamotrigine have not been established. Therefore, routine monitoring is not required. Dosage is titrated to efficacy and tolerability.

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

Get My Free Ebook


Post a comment