## Eer Cer 50 28 per cent 22 per cent

and the difference between the probabilities is 0.22. This means that for every 100 patients treated with a tricyclic antidepressant, compared with placebo, 22 more responded. Therefore, to achieve one more full remission over 12 weeks, 100/22, or about five patients, would need to be treated (NNT) with sertraline.

A 95 per cent confidence interval can also be constructed for the NNT using the following formula to calculate the 95 per cent confidence interval for the absolute risk difference:

JCEEHl-CiiR) EERll - EER)

T Mtrtmifll) NloijHtiiUfntil}

T 1-ao 134

This value is then added to and subtracted from absolute risk difference to produce the confidence interval for the rate, i.e. 0.22 + 0.113 = 0.333 and 0.22 - 0.113 = 0.107. The confidence interval for the NNT can then be calculated by taking the reciprocal of each of these values (NNTs are always rounded up to the nearest integer):

## Funny Wiring Autism

Autism is a developmental disorder that manifests itself in early childhood and affects the functioning of the brain, primarily in the areas of social interaction and communication. Children with autism look like other children but do not play or behave like other children. They must struggle daily to cope and connect with the world around them.

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