Diagnostic accuracy

The predictive validity of the consensus criteria for DLB have not yet been fully established. When retrospectively applied to clinical records of autopsy-confirmed cases(21) they had a sensitivity of 0.75 and specificity of 0.79. Inter-rater reliability was acceptable for all key symptoms with the exception of fluctuation (k = 0.25-0.36). In the first prospective validation study(9) the consensus criteria show a tendency to clinically underdiagnose DLB (sensitivity 0.83); false-positive diagnoses are uncommon (specificity 0.95). Although it is possible within a specialist centre to diagnose DLB with an accuracy similar to that for AD or Parkinson's disease, further clarification of the criteria would assist in their routine clinical use, particularly for the items relating to fluctuating cognition.

Funny Wiring Autism

Funny Wiring Autism

Autism is a developmental disorder that manifests itself in early childhood and affects the functioning of the brain, primarily in the areas of social interaction and communication. Children with autism look like other children but do not play or behave like other children. They must struggle daily to cope and connect with the world around them.

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