Course and prognosis

Early-onset epilepsies are associated with cognitive, behavioural, and communication disorders. Moreover, there is evidence that both clinical and subclinical epilepsy may result in developmental deviance, which has led to earlier and more aggressive treatment to try to prevent these impairments. Psychosocial factors are important in impairment. One prospective study evaluated 220 adults with childhood-onset seizures (6 64) up to age 35. The majority of subjects were free of seizures as adults, but were at risk for social and educational problems. When compared with random control subjects, those with epilepsy demonstrated correlations between neurological and cognitive impairment and social deficits. Those with epilepsy only (100 subjects) had a fourfold risk of psychiatric disorder. The authors reported social adjustment problems, competence problems, and reduction in marriage rate and fertility.

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