Course and prognosis

The course of HIV-associated dementia is variable, and no predictor of the pace of progression is currently available. The syndrome often progresses rapidly to severe deterioration and death, especially in patients with advanced systemic disease, but it may also have prolonged stable phases, or may fluctuate, with reversible deterioration occurring in concomitance with opportunistic infections. Death usually occurs as a result of inanition, aspiration pneumonia, or systemic opportunistic infections.

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