Conclusions

Understanding the operation of networks of neurones provides valuable insight into a range of neurological and psychiatric diseases. The role of synaptic networks of excitatory neurones in focal epilepsies is now well established. The ways in which brief epileptic discharges transform into events lasting as long as full seizures are starting to be clarified, and may offer new avenues for developing rational therapies. New ideas on the generation of physiological rhythms suggest novel models of psychiatric and neurological problems ranging from impairments in learning and memory in limbic epilepsies to (more speculatively) the disruption of sensory perception in psychoses. Real clinical cases will inevitably be much more complex, but the ideas and models outlined above will aid the understanding of the underlying mechanisms.

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