Comparison between FLD and Picks disease

The clinical similarities between FLD and Pick's disease are important, in spite of differences in histopathology and distribution of brain pathology. Deterioration of personality and behaviour, expressive speech disorder, and gradual loss of mimical expression are found in both diseases as are an early normal EEG, incontinence, and low and labile blood pressure. Severe memory failure and confabulation are probably more prevalent in Pick's disease, while affective symptoms, especially depression, are more often reported in FLD. The analysis of larger patient materials and the use of functional brain imaging, and genetic and other biological markers will further elucidate the relationship between FLD and Pick's disease.

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