The use of carbamazepine in schizophrenia has not been systematically researched and rests on anecdotal evidence. It may be considered as an alternative mood stabilizer in those with schizoaffective disorder, although another adjunctive use in schizophrenia may lie with those patients who have intransigent symptomatology, with a perceptual emphasis, reminiscent of temporal lobe disorder, even when the routine EEG is normal. A further indication may be patients whose EEG abnormalities show a temporal localization without clinical fits. Carbamazepine induces the metabolism of some antipsychotics, which may necessitate raising doses of the latter to prevent a paradoxical deterioration.

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