Bupropion is an antidepressant with a pharmacological profile similar to that of stimulants. Conners et a/A1.85) reported that bupropion significantly improves the symptoms of AD-HKD without any concomitant deterioration in cognitive performance or serious side-effects. A direct comparison with methylphenidate found that bupropion is less effective in improving attention, but is otherwise comparable.(l86) Bupropion, however, may induce or aggravate tics, making it a poor choice for children with AD-HKD and comorbid tic disorders. Persons taking bupropion should also be monitored for skin rashes and electroencephalographic abnormalities.

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