Benzodiazepinereceptor partial agonists

As described earlier, the disadvantages of the benzodiazepines include sedation, psychomotor and cognitive impairment, and withdrawal symptoms after long-term use. Increased understanding of benzodiazepine-receptor mechanisms suggested that compounds might be developed which are partial agonists and/or selective to some subtypes of receptor.(34) Such compounds would be less efficacious than full agonists but might have better adverse-effect profiles and less dependence potential, i.e. superior risk-benefit ratios.

One such compound, alpidem, was actually marketed in France but had to be withdrawn because of liver toxicity. Initial data suggested that it was somewhat less effective than a typical full benzodiazepine agonist but that it had a distinctly better side-effect profile. (36).

Abecarnil is a b-carboline which is anxiolytic in doses of 3 to 9 mg/day. However, efficacy has been difficult to demonstrate convincingly, although the side-effect profile does appear to resemble that of a comparator benzodiazepine.

Do Not Panic

Do Not Panic

This guide Don't Panic has tips and additional information on what you should do when you are experiencing an anxiety or panic attack. With so much going on in the world today with taking care of your family, working full time, dealing with office politics and other things, you could experience a serious meltdown. All of these things could at one point cause you to stress out and snap.

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