Autoimmune factors

Recently, a strong association has been demonstrated between OCD and Sydenham's chorea, a childhood movement disorder associated with rheumatic fever which is thought to be a result of an antineuronal antibody-mediated response to group A b-haemolytic streptococcus ( GABHS), directed at portions of the basal ganglia.(41) OCD or some of its symptoms are seen in 70 per cent of Sydenham's chorea cases. Swedo et al.(42) have also documented post-streptococcal cases of OCD and/or tics in children and adolescents, without the neurological symptoms of Sydenham's chorea, giving them the acronym of PANDAS (paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections). Therapeutically, this finding of a probable autoimmune-caused OCD raises the clinical possibility that immunosuppressant and even antibiotic treatments will be effective in treating or preventing some cases of OCD. An antigen labelled D8/17, on the surface of peripheral blood mononuclear cells has been shown to be a marker for the genetic tendency to generate abnormal antibodies to GABHS. Two independent groups of researchers have found a greater expression of the D8/17 antigen in the B lymphocytes of patients with childhood-onset OCD or Tourette's disorder compared with healthy controls, indicating that the presence of the D8/17 antigen may serve as a marker of susceptibility for OCD. (39)

Adult Dyslexia

Adult Dyslexia

This is a comprehensive guide covering the basics of dyslexia to a wide range of diagnostic procedures and tips to help you manage with your symptoms. These tips and tricks have been used on people with dyslexia of every varying degree and with great success. People just like yourself that suffer with adult dyslexia now feel more comfortable and relaxed in social and work situations.

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