Autoimmune disorders Systemic lupus erythematosus

Systemic lupus erythematosus is characterized by the production of autoantibodies that injure tissue in several organ systems, most frequently the skin, central nervous system, kidney, and lungs. In addition, non-specific symptoms occur in a large majority of patients, including fatigue, fever, weight loss, arthralgias, and myalgias.(74) The most common presenting symptoms are fever, arthralgias, butterfly rash, photosensitivity, Raynaud's phenomenon, and mucous ulcers. The laboratory diagnostic hallmark of systemic lupus erythematosus is the production of high-titre autoantibodies directed against a variety of cell nucleus components (antinuclear antibodies). Systemic lupus erythematosus has no known cure, so treatment is based on symptom relief, suppression of inflammation, and preventing future pathology.

The most common psychiatric presentations of active systemic lupus erythematosus are psychosis, delirium, primary generalized seizures, complex partial seizures, and global cognitive dysfunction.(75) Autoantibodies to neuronal membranes, which interfere with the ability of neurones to respond to stimuli, may account for most neuropsychiatric deficits and symptoms/76' though CNS vasculitis during the course of this disease may also play a role in some patients. Mood syndromes are probably the most common psychiatric presentation of patients with systemic lupus erythematosus, (77,78> but mood change is not always due to involvement of the central nervous system. Patients are frequently treated with steroids, which raises the possibility of steroid-induced neuropsychiatric syndromes. However, in many cases, addition of steroids to treatment may improve psychiatric syndromes. Metabolic derangements in patients with systemic lupus erythematosus (e.g. renal dysfunction) may increase the risk of seizures and delirium.(76)

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

Get My Free Ebook


Post a comment